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Furaprofen

CAS No. : 67700-30-5

MCE 站：Furaprofen

产品活性：Furaprofen (R803) 是一种有效的 HCV 复制抑制剂。作用于 HCV 基因型 1a 和 1b 复制子时 EC₅₀ 约为 30 nM，作用于基因型 2a 复制子时 EC₅₀ 约为 1000 nM。

研究领域：Anti-infection

作用靶点：HCV

In Vitro: Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC₅₀) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.

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