MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Zatosetron maleate

CAS No. : 123482-23-5

MCE 站：Zatosetron maleate

产品活性：Zatosetron maleate 是一个有效且有选择性的 5HT3 受体拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vivo: Acute administration of 0.1 (n=21) and 0.3 (n=5) mg/kg Zatosetron maleate (Zatosetron) in male rats, but not 0.01, 0.05, 1.0 or 10 mg/kg (n=5, 3, 6 and 4, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells. The number of spontaneously active A10 dopamine cells is not significantly different from 30 to 60 min post i.p. Zatosetron maleate (0.1 mg/kg) administration, shows a significant decrease by 60 to 90 min (0.65±0.11, P=0.03, n=5), a larger decrease by 90 to120 min (0.53±0.08, P=0.004, n=5) and remains at this significantly decreased level from 2 to 3 h (0.50+0.05, P=0.0004, n=5). Single-unit recordings show that Zatosetron maleate inhibits the activity of A10 dopamine cells following i.v. administration (ED₅₀=0.12 mg/kg, n=8). Chronic administration of 0.1 mg/kg (n=16) Zatosetron maleate, but not 0.01, 1.0 or 10 mg/kg (n=4, 8 and 7, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells.

相关产品：Harmine  |  SCH-23390 hydrochloride  |  Puerarin  |  Olanzapine  |  GTS-21 dihydrochloride  |  Thioridazine hydrochloride  |  Risperidone  |  SB-269970 hydrochloride  |  Dihydroergotamine mesylate  |  Amitriptyline hydrochloride  |  Aripiprazole  |  Ketanserin  |  WAY-100635 Maleate  |  Buspirone hydrochloride  |  Cisapride  |  Methiothepin mesylate  |  Trazodone hydrochloride  |  Pindolol  |  Quetiapine  |  Lumateperone tosylate  |  Perphenazine  |  8-OH-DPAT  |  Levomepromazine  |  SB-224289 hydrochloride  |  Volinanserin  |  Ziprasidone  |  Paliperidone  |  Sertindole  |  Alprenolol hydrochloride  |  Asenapine maleate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。