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Saperconazole

CAS No. : 110588-57-3

MCE 站：Saperconazole

产品活性：Saperconazole (R66905) 是一种广谱的抗真菌性三唑，具有很强的抗曲霉菌活性，其 MIC₉₀ 值为 0.19 mg/L。

研究领域：Anti-infection

作用靶点：Fungal

In Vitro: The antifungal activity of Saperconazole is complete at 1 μg/mL for all but one strain of A. niger. Eighty percent of all strains show complete absence of growth at 0.1 μg/mL (85% for A. fumigatus), and this result persists during 14 days of the test.

In Vivo: All control pigeons infect with A. fumigatus die within 2 to 5 days. They have necrotic foci in the lungs, air sacs, liver, spleen, and kidneys. These organs are highly positive by histology and oncultures. Saperconazole administered at 2.5 mg/kg is not active, but when it is given at 5 or 10 mg/kg, 92 or 100%, respectively, survive and organ cultures are negative. No drug-related side effects are observed in the pigeons.

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