MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BCI-121

CAS No. : 432529-82-3

MCE 站：BCI-121

产品活性：BCI-121是能够抑制癌症细胞增殖的 SMYD3 抑制剂。

研究领域：Epigenetics

作用靶点：Histone Methyltransferase

In Vitro: BCI-121 significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types. BCI-121 significantly reduces proliferation of HT29 (by 46%) and HCT116 (by 54%) cells at 72 h and decreases the expression levels of SMYD3 target genes. SMYD3 preferentially methylates histone H4, and the presence of BCI-121 impairs SMYD3-mediated H4 in vitro methylation. Cancer cells treated with BCI-121 show a significant reduction in their growth ability and accumulated in the S phase of the cell cycle. Cells treated with BCI-121 shows a dose-dependent relationship between SMYD3 impairment and both inhibition of proliferation and reduction of targeted methyl marks (H4K5me and H3K4me2). BCI-121 shows antiproliferative properties in cancer cell lines overexpressing SMYD3 and, in general, replicated the effects of SMYD3-targeted RNAi. Experiments performed in cancer cells show that BCI-121 prevents SMYD3 recruitment on the promoters of its target genes and this event is correlated with reduced gene expression.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Reprogramming Compound Library  |  Anti-Blood Cancer Compound Library  |  3-Deazaneplanocin A hydrochloride  |  Chaetocin  |  UNC0642  |  UNC1999  |  MS023  |  BIX-01294  |  EPZ020411 hydrochloride  |  MM-102 TFA  |  SGC0946  |  A-366  |  Amodiaquine dihydrochloride dihydrate  |  CM-272  |  AZ505  |  SGC707  |  PFI-2 hydrochloride  |  NSC 663284  |  UNC0379  |  A-196  |  Sinefungin  |  SGC3027  |  AMI-1  |  EI1  |  BVT948  |  MS049  |  HLCL-61 hydrochloride  |  UNC0646  |  UNC 0631  |  UNC3866

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。