MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Repotrectinib

CAS No. : 1802220-02-5

MCE 站：Repotrectinib

产品活性：Repotrectinib (TPX-0005) 是一种有效的 ROS1 (IC₅₀=0.07 nM) 和 TRK (对 TRKA/B/C 的 IC₅₀=0.83/0.05/0.1 nM) 抑制剂。Repotrectinib 有效抑制 WT ALK (IC₅₀=1.01 nM)。Repotrectinib 具有抗癌活性。

研究领域：Protein Tyrosine Kinase/RTK  |  Neuronal Signaling

作用靶点：ROS  |  Trk Receptor  |  ALK

In Vitro: Repotrectinib (TPX-0005) inhibits mutant ALKs including ALK G1202R (IC₅₀=1.26 nM) and ALK L1196M (IC₅₀=1.08 nM). Repotrectinib also inhibits a variety of other kinases, including JAK2, LYN, Src, and FAK (IC₅₀=1.04, 1.66, 5.3, and 6.96 nM, respectively).
Repotrectinib effectively overcomes this primary resistance (IC₅₀=100 nM in cell proliferation assay) with strong inhibition of the phosphorylation of EML4-ALK (IC₅₀=13 nM) and the SRC substrate paxillin (IC₅₀=107 nM). Repotrectinib inhibits H2228 cell migration in a wound healing assay with similar activity to saracatinib.

In Vivo: Repotrectinib (TPX-0005) effectively inhibits tumor growth in vivo in ALK WT and ALK G1202R xenografts.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  Anti-Lung Cancer Compound Library  |  A 83-01  |  ANA-12  |  K-252a  |  Lestaurtinib  |  Amitriptyline hydrochloride  |  7,8-Dihydroxyflavone  |  AZD-3463  |  GNF-5837  |  β-Carotene  |  AZ-23  |  Tavilermide  |  LM22A-4  |  N-Acetyl-5-hydroxytryptamine  |  ALK inhibitor 1  |  TrkA-IN-1  |  Tyrphostin AG 879  |  X-376  |  ALK inhibitor 2  |  HG-14-10-04  |  6-Demethoxytangeretin  |  JH-VIII-157-02  |  ALK/ROS1-IN-1  |  Cinnamtannin B-1  |  Cyclotraxin B  |  F-1  |  TGFβRI-IN-2  |  TL13-110  |  TL13-22  |  Ensartinib

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。