MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Cintirorgon

CAS No. : 2055536-64-4

MCE 站：Cintirorgon

产品活性：Cintirorgon (LYC-55716) 是一种首创的、选择性的，具有口服活性的 RORγ 激动剂。Cintirorgon (LYC-55716) 调节 RORγ 表达的 T 淋巴细胞免疫细胞的基因表达，增强效应子功能，降低免疫抑制，降低肿瘤生长，提高生存率 。

研究领域：Metabolic Enzyme/Protease

作用靶点：ROR

In Vivo: Upon oral administration of RORγ agonist Cintirorgon (LYC-55716), this agent selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus, and binds to ROR response elements (ROREs), enhancing the function, proliferation and survival of type 17 T cells, including Th17 (helper T cells) and Tc17 (cytotoxic T cells). RORγ, the nuclear receptor transcription factor that is involved in Th17/Tc17 differentiation, plays a key role in immune activation. Cintirorgon (LYC-55716) is also orally bioavailable, while the new generation of immuno-oncology drugs-ncluding PD-1/PD-L1 inhibitors are delivered by injection.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  T0901317  |  Nobiletin  |  SR3335  |  SR1078  |  SR1001  |  GSK805  |  3-Oxo-5β-cholanoic acid  |  SR0987  |  TMP920  |  Neoruscogenin  |  S18-000003  |  RORγt Inverse agonist 8  |  Methyl-3β-hydroxycholenate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。