MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CCCP

CAS No. : 555-60-2

MCE 站：CCCP

产品活性：CCCP 是氧化磷酸化 (OXPHOS) 解偶联剂。CCCP 诱导 PINK1 激活，促进 Parkin 在 Ser65 位点磷酸化。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease  |  Anti-infection  |  Apoptosis

作用靶点：STING  |  IFNAR  |  Mitochondrial Metabolism  |  Bacterial  |  Apoptosis

In Vitro: CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

In Vivo: The same dosage of 3?mg/kg.bw each of CCCP and PPEF is used. In both the cases 1?log reduction is observed in the bacterial load. However, when 3?mg/kg.bw of PPEF is used in combination with 3?mg/kg.bw of CCCP, 6 log₁₀ reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy.^99mTc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. ^99mTc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by ³¹P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the ^99mTc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after ^99mTc-MIBI injection, the ^99mTc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Antibacterial Compound Library  |  Pyroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Paclitaxel  |  Y-27632 dihydrochloride  |  Acetylcysteine  |  Angiotensin II human  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Dexamethasone  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Verteporfin  |  Doxycycline (hyclate)  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  G-418 disulfate  |  5-Azacytidine  |  BAY 11-7082  |  Etoposide  |  Mitomycin C  |  DAPT  |  Nigericin sodium salt

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。