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Etofibrate

CAS No. : 31637-97-5

MCE 站：Etofibrate

产品活性：Etofibrate 是烟酸和氯贝酸的醚二醇-1,2 二酯。Etofibrate 在动物和人类中是有效的降血脂剂。

研究领域：Others

作用靶点：Others

In Vivo: Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human. After 10 days of treatment with Etofibrate, the rats show a body weight similar to that found in the control animals but their liver weight is significantly enhanced whereas plasma cholesterol and triacylglycerol levels are decreased. Etofibrate treatment increases the bile flow of the animals, the effect being especially manifest during the first 2 hr after interruption of the enterohepatic circulation and the difference with the controls becomes statistically significant at 30 and 90 min. The cumulative amount of bile secreted plotted against time shows a highly significant linear correlation for both control and Etofibrate treated rats, the slope being significantly higher for the Etofibrate group than for controls.

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