MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Fuscoside

CAS No. : 131631-89-5

MCE 站：Fuscoside

产品活性：Fuscoside (OPC-21268) 是一种口服有效的非多肽类加压素受体 (vasopressin V1) 拮抗剂， IC₅₀ 值为0.4 μM。

研究领域：GPCR/G Protein

作用靶点：Vasopressin Receptor

In Vitro: The concentration of Fuscoside (OPC-21268) that displaces 50% of specific AVP binding (IC₅₀) is 0.4 μM for VI receptors and 100 μM for V2 receptors. The inhibition constant (K_i) of Fuscoside (OPC-21268) for V1 receptors (0.14 μM).

In Vivo: Fuscoside (OPC-21268) competitively and specifically antagonizes pressor responses to AVP in vivo. Oral administration of Fuscoside (OPC-21268) (10 mg/kg) inhibits the vasoconstriction induced by exogenous AVP in a dose- and time-dependent manner and the effect lasts for more than 8 hours at 30 mg/kg. Fuscoside (OPC-21268) predominantly exerts a protective effect in areas where the maximum amount of blood-brain barrier breakdown occurs, and it is effective in the treatment of cold-induced vasogenic brain edema. Fuscoside (OPC-21268) treatment at the dosages of 200 and 300 mg/kg significantly reduces brain water content in both hemispheres. Swelling of the traumatized hemispheres is also significantly reduced at 200 and 300 mg/kg dosages.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Endocrinology Compound Library  |  Orally Active Compound Library  |  Argipressin  |  Conivaptan hydrochloride  |  Atosiban  |  Tolvaptan  |  Felypressin  |  Lixivaptan  |  Terlipressin acetate  |  Mozavaptan  |  SRX246  |  Big Endothelin-1 (1-38), human  |  D[LEU4,LYS8]-VP TFA  |  L-371,257  |  SKF 100398  |  WAY-151932  |  Antagonist G  |  Big Endothelin-1 (1-39), porcine  |  d[Cha4]-AVP

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。