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KD-3010

CAS No. : 934760-92-6

MCE 站：KD-3010

产品活性：KD-3010 是一种具有口服活性的有效的选择性 PPARδ 激动剂。

研究领域：Cell Cycle/DNA Damage

作用靶点：PPAR

In Vivo: To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl₄) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl₄, and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl₄ on H&E-stained liver sections but is markedly reduced in the KD3010-treated group.

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