MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CU-CPT-8m

CAS No. : 125079-83-6

MCE 站：CU-CPT-8m

产品活性：CU-CPT-8m 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 67 nM。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: CU-CPT-8m is a specific TLR8 antagonist, with an IC₅₀ of 67±10 nM and negligible cytotoxicity. The K_d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC₅₀ of 90±10 nM, which is in good agreement with its IC₅₀ value determined in HEK-Blue TLR8 cells.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Chloroquine  |  Resatorvid  |  Resiquimod  |  Hydroxychloroquine sulfate  |  C29  |  Imiquimod  |  Sulfo-ara-F-NMN  |  Polyinosinic-polycytidylic acid sodium  |  CU-T12-9  |  MD2-IN-1  |  Schaftoside  |  TH1020  |  IAXO-102  |  Atractylenolide I  |  TLR7/8 agonist 1 dihydrochloride  |  DSR-6434  |  TLR4-IN-C34  |  Sparstolonin B  |  Isofraxidin  |  Procyanidin B1  |  CU-CPT17e  |  Robinin  |  Loxoribine  |  CL075  |  FSL-1 TFA  |  Okanin  |  Polygalasaponin F  |  Bropirimine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。