MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CU-CPT9b

CAS No. : 2162962-69-6

MCE 站：CU-CPT9b

产品活性：CU-CPT9b 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 0.7 nM。CU-CPT9b 高亲和性结合 TLR8， K_d 值为 21 nM。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: CU-CPT9b is a specific TLR8 antagonist, with an IC₅₀ of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a K_d of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Chloroquine  |  Resatorvid  |  Resiquimod  |  Hydroxychloroquine sulfate  |  C29  |  Imiquimod  |  Sulfo-ara-F-NMN  |  Polyinosinic-polycytidylic acid sodium  |  CU-T12-9  |  MD2-IN-1  |  Schaftoside  |  TH1020  |  IAXO-102  |  CU-CPT-8m  |  Atractylenolide I  |  TLR7/8 agonist 1 dihydrochloride  |  DSR-6434  |  TLR4-IN-C34  |  Sparstolonin B  |  Isofraxidin  |  Procyanidin B1  |  CU-CPT17e  |  Robinin  |  Loxoribine  |  CL075  |  FSL-1 TFA  |  Okanin  |  Polygalasaponin F

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。