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AZ32

CAS No. : 2288709-96-4

MCE 站：AZ32

产品活性：AZ32 是一种口服可利用的，可穿透血脑屏障的 ATM 抑制剂，IC₅₀<6.2 nM。在细胞中抑制 ATM，IC₅₀ 为 0.31 μM。

研究领域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR

作用靶点：ATM/ATR

In Vitro: AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.

In Vivo: AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC₅₀ for approximately 22 hours.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  AZ20  |  CGK733  |  CP-466722  |  ETP-46464  |  Garci C  |  Ro 90-7501  |  NU6027

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