您好,欢迎来到易推广 请登录 免费注册

MedChemExpress 主营产品:Medchemexpress,抑制剂专家,生物试剂公司

易推广认证请放心拨打

021-58955995

当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > MCE信号通路 > 代谢酶/蛋白酶 > ABT-702 dihydrochloride

提示:信息由商家自行发布,信息的真伪性请消费者自己判断,信息内容的准确性由相关商家负责,易推广对此不承担任何责任。

ABT-702 dihydrochloride

价格:¥电议

品牌名称:$brandModel.Title(进口品牌)型号: 原产地:美洲 发布时间:2021/8/3更新时间:2024/1/2

产品摘要:ABT-702 dihydrochloride 是一种有效的腺苷激酶 (AK) 抑制剂 (IC50=1.7 nM)。

产品完善度: 访问次数:1619

企业档案

会员类型:会员

已获得易推广信誉   等级评定
171成长值

(0 -40)基础信誉积累,可浏览访问

(41-90)良好信誉积累,可接洽商谈

(91+  )优质信誉积累,可持续信赖

易推广会员:8

工商认证 【已认证】

最后认证时间:

注册号: 【已认证】

法人代表: 【已认证】

企业类型:生产商 【已认证】

注册资金:人民币万 【已认证】

产品数:91228

参观次数:11308024

手机网站:http://m.yituig.com/c131527/

旗舰版地址:http://medchemexpress.app17.com

联系我们

MedChemExpress

电话:021-58955995

联系人:客服部 (请说明是在易推广看到的!谢谢)

手机:13611715263

邮编:201203

邮箱:sales@medchemexpress.cn

地址:上海上海

详细内容

联系方式:
电话:021-58955995 手机:13611715263 联系人:客服部   Q Q:4008203792

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。

ABT-702 dihydrochloride

CAS No. : 1188890-28-9

MCE 站:ABT-702 dihydrochloride

产品活性:ABT-702 dihydrochloride 是一种有效的腺苷激酶 (AK) 抑制剂 (IC50=1.7 nM)。

研究领域:Metabolic Enzyme/Protease  |  Neuronal Signaling

作用靶点:Adenosine Kinase

In Vitro: ABT-702 is an orally effective adenosine kinase inhibitor that has several orders of magnitude selectivity over other sites of adenosine (ADO) interaction (A1, A2A, A3 receptors, ADO transporter, and ADO deaminase). ABT-702 is equipotent (IC50=1.5±0.3 nM) in inhibiting native human AK (placenta), two human recombinant isoforms (AKlong and AKshort), and AK from monkey, dog, rat, and mouse brain. ABT-702 potently inhibits the activity of rat brain cytosolic AK in a concentration-dependent manner with an IC50 value of 1.7 nM. ABT-702 also potently inhibits AK activity in intact cultured IMR-32 human neuroblastoma cells (IC50=51 nM), indicating that ABT-702 can penetrate the cell membrane and potently inhibit AK at its intracellular site.

In Vivo: ABT-702 significantly reduces acute thermal nociception in a dose-dependent manner after both intraperitoneal (ED50=8 μmol/kg i.p.) and oral (ED50=65 μmol/kg p.o.) administration in the mouse hot-plate test. Consistent with its antinociceptive effects in the hot-plate assay, ABT-702 also produces dose-dependent antinociceptive effects (ED50=2 μmol/kg i.p.) in the abdominal constriction assay. Like Morphine (21 μmol/kg i.p.), ABT-702 exhibits full efficacy in this model of persistent chemical pain. Rats are given an intraperitoneal injection of the adenosine A1 receptor antagonist DPCPX (3 mg/kg), ABT-702 (3 mg/kg), or vehicle 10 minutes prior to an intravenous injection of 2-18F-fluorodeoxy-D-glucose (FDG) (FDG, 15.4±0.7 MBq per rat). Rats are then subjected to a 15 minute static positron emission tomography (PET) scan. Reconstructed images are normalized to FDG PET template for rats and standard uptake values (SUVs) are calculated. To examine the regional effect of active treatment compared to vehicle, statistical parametric mapping analysis is performed. Whole-brain FDG uptake is not affected by drug treatment. Significant regional hypometabolism is detected, particularly in cerebellum, of DPCPX and ABT-702 treated rats, relative to vehicle-treated rats. Thus, endogenous adenosine can affect FDG accumulation although this effect is modest in quiescent rats. Body weight (316.8±28.4 g; mean±SD) and blood glucose (5.5±1.7 mM) are not significantly different among three groups. Whole-brain PET SUV values are 1.6±0.4, 1.6±0.6, and 1.8±0.6 for vehicle, ABT-702, and DPCPX-treated rats, respectively (F(2,9)=0.298, P=0.75). statistical parametric mapping (SPM) analysis reveals significant regional hypometabolism in the cerebellum, mesencephalic region, and medulla in the ABT-702-treated rats compared to the vehicle-treated rats.

相关产品:Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Diabetes Related Compound Library  |  5-Iodotubercidin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
•   设有专业的实验中心和严格的质控、验证体系;
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
•   产品的生物活性多经各国客户实验验证;
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
•   专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
•   与世界各大制药公司及知名科研机构建立了长期的合作。

1000+ Inhibitors&Agonists 作用于20多条经典信号通路
30+ Screening Libraries 疾病机制研究的高效工具
CCK8 Kit | Cell Counting Kit-8
FDA-Approved 药物筛选库
Inhibitor Cocktails 蛋白酶, 磷酸酶 & 去乙酰化酶
Top Publications Citing Use of MCE
MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持
联系方式:
电话:021-58955995 手机:13611715263 联系人:客服部   Q Q:4008203792

热门标签:abt-702 

快速导航

在线咨询

提交