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Phenylbiguanide

CAS No. : 102-02-3

MCE 站：Phenylbiguanide

产品活性：Phenylbiguanide 是一种选择性的 5-HT₃ 受体激动剂，EC₅₀ 为 3.0±0.1 μM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vitro: Phenylbiguanide (1-Phenylbiguanide) is a 5-HT₃ receptor selective agonist with pEC₅₀s of 5.57, 4.07, and 4.47 for r5-HT_3A(b), h5-HT_3A, m5-HT_3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).

In Vivo: In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.

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