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BIO-acetoxime

CAS No. : 667463-85-6

MCE 站：BIO-acetoxime

产品活性：BIO-acetoxime (BIA) 是一种有效、选择性的 GSK-3 抑制剂，对 GSK-3α/β 的 IC₅₀ 值均为 10 nM；BIO-acetoxime 具有抗惊厥和抗感染作用。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  Apoptosis  |  Anti-infection

作用靶点：GSK-3  |  Apoptosis  |  HSV

In Vitro: BIO-acetoxime (BIA; Compound 13) is a potent and selective GSK-3α/β inhibitor, with IC₅₀s of both 10 nM. BIO-acetoxime (BIA) shows weak effect on CDK5/p35 (IC₅₀, 2.4 μM), CDK2/cyclin A (IC₅₀, 4.3 μM), and CDK1/cyclin B (IC₅₀, 63 μM). BIO-acetoxime (BIA) (5 μM and 10 μM) increases the viability of HSV-1-infected cells but shows little effect on morphology and viability of mockin-fected cells. Moreover, BIO-acetoxime (BIA) (0.625, 1.25, 2.5, 5, and 10 μM) significantly reduces the release of HSV-1 particles in OC3 cells, with an EC₅₀ of 0.68 ± 0.28 μM. BIO-acetoxime (BIA) inhibits the expression of HSV-1 genes, and may not affect the nuclear targeting of HSV-1 capsids. In addition, delayed addition of BIO-acetoxime (BIA) also inhibits HSV-1 infection.

In Vivo: BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration.

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