MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BM-1197

CAS No. : 1391107-89-3

MCE 站：BM-1197

产品活性：BM-1197 是一种有效的和选择性的 Bcl-2/Bcl-xL 的双重抑制剂，抑制 Bcl-2 和 Bcl-xL 的 IC₅₀ 值分别为 3.5 nM 和 5.2 nM。BM-1197 在体外和体内均表现出抗肿瘤作用。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: BM-1197 (2-2000 nM; 3 d) has marginal cytotoxicity against wild-type mouse embryonic fibroblast (MEF) cells but exerts potent growth-inhibitory activity in the MCL1^?/? cells.
BM-1197 shows potent growth-inhibitory activities in 7 small cell lung cancer (SCLC) cell lines with IC₅₀s <100 nM, moderate activity in 3 SCLC cell lines with IC₅₀s of ?600 nM and weak activity in 2 SCLC cell lines with IC₅₀s >2000 nM.
BM-1197 (100 nM; 16 h) potently induces apoptosis in H146 cells.
BM-1197 (100 nM; 2 h) disrupts the association between Bcl-xl and Puma or Bim in H146 cells.
BM-1197 (100 nM; 0.5-2 h) induces Bax translocation, and it (3-30 nM; 2 h) induces cytochrome c release in H146 cells.

In Vivo: BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model.
BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses.
BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models.

相关产品：Venetoclax  |  BT2  |  Chelerythrine chloride  |  Bax inhibitor peptide V5  |  A-1210477  |  BAI1  |  Dehydrocorydaline chloride  |  Gambogic Acid  |  Gossypol  |  BI-3812  |  Clitocine  |  PROTAC Bcl2 degrader-1  |  (R)-(-)-Gossypol acetic acid  |  MIM1  |  TW-37  |  (E)-Ferulic acid  |  Jaceosidin  |  Paris saponin VII  |  Bz 423  |  Dihydrokaempferol  |  MSN-125  |  HA14-1  |  TCPOBOP  |  BH3I-1  |  Thevetiaflavone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。