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OSMI-2

CAS No. : 2260542-60-5

MCE 站：OSMI-2

产品活性：OSMI-2 (Compound 1b) 是一种可渗透细胞的 O-GlcNAc 转移酶 (OGT) 抑制剂。细胞包含部分剪接的 OGT 转录本的核库，OSMI-2 增加了细胞中保留的内含子剪接。

研究领域：Metabolic Enzyme/Protease

作用靶点：Acyltransferase

In Vitro: OSMI-2 (Compound 1b; 20-50 μM; 4-24 hours; HCT116 cells) treatment reduces O-GlcNAc levels at short treatment times (<8h). However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2.A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 (Compound 1b) is observed. Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored. Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.
A time course performed with 20 μM OSMI-2 (Compound 1b) shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT; this may explain the recovery in O-GlcNAc levels with OSMI-2. At 24h where O-GlcNAc levels fully recovered.

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