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DDP-38003 dihydrochloride

CAS No. : 1831167-98-6

MCE 站：DDP-38003 dihydrochloride

产品活性：DDP-38003 dihydrochloride是新颖有口服活性的KDM1A/LSD1抑制剂，IC₅₀值为84 nM。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: DDP-38003 inhibits KDM1A with an IC₅₀ of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.

In Vivo: DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.

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