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Randialic acid B

CAS No. : 14021-14-8

MCE 站：Randialic acid B

产品活性：Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, ａnd CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, ａnd hFPR1-transfected HEK293 cells, indicating FPR1 antagonism.
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca²⁺ mobilisation ａnd activation of Akt ａnd MAPKs is also competitively inhibited.
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury.

In Vivo: Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, ａnd transepidermal water loss.

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