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LPRP-Et-97543

CAS No. : 84638-48-2

MCE 站：LPRP-Et-97543

产品活性：LPRP-Et-97543 是一种有效的抗 HBV 药物。LPRP-Et-97543 降低 Core、S 和 preS 活性，但不降低 X 启动子活性。LPRP-Et-97543 可用于急性和慢性 HBV 感染研究。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: LPRP-Et-97543 (0.625-40 μg/ml; 3 days) causes cytotoxic effects at doses >10 μg/ml in HepG2.2.15 ａnd HBV-transfected Huh7 cells.
LPRP-Et-97543 (2.5-10 μg/ml; 3 days) has inhibitory effects on HBsAg ａnd HBeAg secretions. And the HBeAg inhibition rate is higher than the HBsAg inhibition rate in HepG2.2.15 cells.
LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) significantly reduces both precore/pregenomic ａnd major S/preS RNA with the LPRP-Et-97543 inhibition potential higher on surface RNA than on the precore/pregenomic RNA.
LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) potently reduces intracellular LHBsAg ａnd HBcAg protein levels compared to vehicle controls. Additionally, LPRP-Et-97543 potently inhibits the replication HBV DNAlevel in HBV transfected Huh7 cells.
LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) reduces nuclear p65/p50 NF-κB protein expression ａnd reduces phosphorylated NF-κBp65 in Huh7 cells.

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