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Hypotaurine

CAS No. : 300-84-5

MCE 站：Hypotaurine

产品活性：Hypotaurine (2-aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸的牛磺酸生物合成中间体，是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。抗氧化剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Hypotaurine ａnd taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation ａnd invasion.

In Vivo: Hypotaurine has antinociceptive effects on thermal, mechanical, ａnd chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia ａnd thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, ａnd neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.

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