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Adenosine 5＇-monophosphate monohydrate

CAS No. : 18422-05-4

MCE 站：Adenosine 5＇-monophosphate monohydrate

产品活性：Adenosine 5＇-monophosphate monohydrate 是一个腺苷 A₁ 受体 (adenosine A₁ receptor) 激动剂。Adenosine 5＇-monophosphate monohydrate 对 HSV-1 和 HSV-2 具有显着的抗病毒活性。

研究领域：GPCR/G Protein  |  Anti-infection

作用靶点：Adenosine Receptor  |  HSV

In Vitro: Adenosine 5＇-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5＇-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells. Adenosine 5＇-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) ａnd interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α ａnd IL-6 mRNA show that at concentration of 400 μM, Adenosine 5＇-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5＇-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, ａnd IL-1β gene promoters.

In Vivo: C57BL/6J mice treated with Adenosine 5＇-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8 h) ａnd 33.3% (24 h), whereas survival rate in Adenosine 5＇-monophosphate monohydrate-treated mice (n=15) is 100% (8 h) ａnd 93.3% (24 h). Serum aspartate transaminase (AST) ａnd alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5＇-monophosphate monohydrate group than in the vehicle group. The area ａnd extent of necrosis is attenuated ａnd the infiltration of inflammatory cells is reduced in the Adenosine 5＇-monophosphate monohydrate group.

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