MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ML351

CAS No. : 847163-28-4

MCE 站：ML351

产品活性：ML351 是一种有效且高度特异的 15-LOX-1 抑制剂，其 IC₅₀ of 200 nM。ML351 对相关同工酶 (5-LOX、血小板 12-LOX、15-LOX-2、绵羊 COX-1 和人COX-2) 表现出良好的选择性(>250倍)。ML351 对 T1D 非肥胖糖尿病小鼠模型的血糖异常和β细胞氧化应激有抑制作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Lipoxygenase

In Vitro: ML351 (1-50 μM; 24 hours) displays no deleterious effects on cellular apoptosis (by caspase activity assay).
ML351 (10-50 μM; 24 h) protects mouse islets in a T1D model in vitro. Islets exposed to proinflammatory cytokines exhibits increased insulin release at 2.5 mM glucose ａnd impaired insulin release in response to 25 mM glucose. However, ML351 restores insulin secretion at 2.5 mmol/L glucose to control levels, ａnd insulin release in response to 25 mM glucose is significantly improved compared with treatment with proinflammatory cytokines alone.
ML351 reverses the stimulation of ROS production in mouse islets in response to proinflammatory cytokines in vitro.

In Vivo: ML351 (0-48 mg/kg; before the beginning of the STZ series ａnd concluding 5 days after the last dose of STZ) protects against diabetes development in an STZ β-cell injury model. ML351 at 24 mg/kg (M24)+ STZ shows significantly less weight reduction compares with control group. M24 shows almost complete protection from hyperglycemia. But M48 ａnd M0 exhibits frank hyperglycemia by day 9 of the study ａnd significantly impaired GTTs.
ML351 (intraperitoneal injection; 0-24 mg/kg; daily for 2 weeks) leads to improved glycemic control ａnd significantly reduced insulitis. The reduction of β-cell death in NOD mice has been suggested to lead to reductions in insulitis, likely by mitigating the chemotactic signals released by dying β-cells. NOD + M24 animals exhibited improved glycemic control compared with NOD + M0 animals.

相关产品：U-73122  |  Zileuton  |  Wedelolactone  |  Nordihydroguaiaretic acid  |  Caffeic acid  |  ML355  |  Indirubin-3＇-monoxime  |  Chebulagic acid  |  Docebe  |  Licofelone  |  Psoralidin  |  Pectolinarigenin  |  S-(+)-Marmesin  |  Lonapalene  |  Xanthatin  |  5-O-Demethylnobiletin  |  2,5-Di-tert-butylhydroqui  |  4-MMPB  |  11-​Keto-​beta-​boswellic acid  |  4＇,5-Dihydroxyflavone  |  Enazadrem  |  FPL 62064  |  Malotilate  |  PF-4191834  |  PGS-IN-1  |  Phenidone  |  β-Boswellic acid  |  3-O-Acetyl-11-hydroxy-beta-boswellic acid  |  Atreleuton

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。