当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > MCE信号通路 > 蛋白偶联受体/G 蛋白 > Olodaterol
Olodaterol
企业档案
会员类型:会员
已获得易推广信誉 等级评定
(0 -40)基础信誉积累,可浏览访问
(41-90)良好信誉积累,可接洽商谈
(91+ )优质信誉积累,可持续信赖
易推广会员:8年
最后认证时间:
注册号: 【已认证】
法人代表: 【已认证】
企业类型:生产商 【已认证】
注册资金:人民币万 【已认证】
产品数:91196
参观次数:10584211
联系我们
MedChemExpress
电话:021-58955995
联系人:客服部 (请说明是在易推广看到的!谢谢)
手机:13611715263
邮编:201203
邮箱:sales@medchemexpress.cn
地址:上海上海
详细内容
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Olodaterol
CAS No. : 868049-49-4
MCE 站:Olodaterol
产品活性:Olodaterol (BI1744) 是一种选择性、长效的 β2-adrenoceptor (β2-AR) 激动剂(EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor)。 Olodaterol 可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Adrenergic Receptor
In Vitro: Olodaterol (0.001~10 nM; fibroblasts) attenuates growth factor-induced motility and proliferation.
Olodaterol (0.1~10 nM; fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades.
Olodaterol (0.001~1000 nM; 30 minutes; fibroblasts) increases intracellular cAMP in a concentration-dependent manner. Olodaterol (0~10 nM; 30 minutes; fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70 % at 10 nM. Olodaterol has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes.
In Vivo: Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weight recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis.
Olodaterol (0.1~3 μg/kg; inhal.; 5 hours) induces a dose-dependent bronchoprotection.
Olodaterol (0.3 and 0.6 μg/kg; inhal.; 24 hours) induces a maximal bronchoprotection of approximately 60 % after 0.5 hours.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Endocrinology Compound Library | NMPA-Approved Drug Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Isoprenaline hydrochloride | Propranolol hydrochloride | ICI 118,551 hydrochloride | Norepinephrine | Phenylephrine hydrochloride | Pimozide | Yohimbine Hydrochloride | Prazosin hydrochloride | Carvedilol | Atenolol | CL 316243 | Amitriptyline hydrochloride | Metoprolol Succinate | Mirabegron | Dexmedetomidine hydrochloride | Pindolol | YS-49 | L-Epinephrine | Nebivolol hydrochloride | Dobutamine hydrochloride | (S)-Timolol Maleate | Perphenazine | Salmeterol | (±)-Bisoprolol hemifumarate | Sertindole | Labetalol hydrochloride | Paliperidone | Phentolamine mesylate
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
热门标签:BI1744