MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PY-60

CAS No. :

MCE 站：PY-60

产品活性：PY-60 是一种靶向膜联蛋白A2 (ANXA2) 的 YAP 转录活性的特异的激活剂 (_Kd=1.4 µM)。PY-60 直接与 ANXA2 结合并拮抗其抑制 YAP 活性的正常细胞功能。

研究领域：Stem Cell/Wnt

作用靶点：YAP

In Vitro: PY-60 targets ANXA2 to activate YAP.
PY-60, a thiazole-substituted derivative, dose-dependently induces luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density (EC₅₀= 1.5 ａnd 1.6 µM, respectively). PY-60 treatment also dose-dependently promoted the association of YAP ａnd TEAD proteins in cells ａnd induced the nuclear localization of YAP in response to increased cell density. PY-60 robustly increases the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 ａnd CTGF) in 293A cells ａnd other human cell lines (that is, MCF10A, HEK293T, H69 ａnd HaCaT), but did not augment the levels of YAP itself (YAP1).
PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.
PY-60 liberates the ANXA2-YAP complex from the cell membrane ａnd competes for ANXA2 binding of phosphoinositides.

In Vivo: PY-60 (10 uM; applied topically to the dorsal skin of wild-type adult C57BL/6 mice over the course of 10 days) promotes a dramatic expansion of keratinocytes ａnd K14-positive precursors, as assessed by hematoxylin ａnd eosin ａnd anti-K14 histological staining at the study end. PY-60 results in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin.

相关产品：Verteporfin  |  AICAR  |  Cytochalasin D  |  ML-7 hydrochloride  |  TED-347  |  YAP/TAZ inhibitor-1  |  Lats-IN-1  |  K-975  |  YAP-TEAD-IN-1 TFA  |  Super-TDU (1-31) (TFA)  |  Super-TDU  |  VT107

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。