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Brefeldin A

CAS No. : 20350-15-6

MCE 站：Brefeldin A

产品活性：Brefeldin A (BFA) 是一种内酯抗生素，是蛋白质运输的特定抑制剂。Brefeldin A 阻断分泌蛋白和膜蛋白从内质网向高尔基体的转运。Brefeldin A 也是一种自噬 (autophagy) 和 mitophagy 抑制剂。Brefeldin A 还是一种 CRISPR/Cas9 激动剂，可抑制 HSV-1病毒，并具有抗癌活性。

研究领域：Autophagy  |  Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：Autophagy  |  CRISPR/Cas9  |  Mitophagy  |  HSV  |  Antibiotic

In Vitro: Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) ａnd shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT ａnd actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A ａnd ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38⁺ HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D ａnd 2D cultures ａnd inhibits the migration ａnd MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231.

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