MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Buparvaquone

CAS No. : 88426-33-9

MCE 站：Buparvaquone

产品活性：Buparvaquone是一种与parvaquone和atovaquone有关的羟基萘醌类抗原虫药。

研究领域：Anti-infection

作用靶点：Parasite  |  Antibiotic

In Vitro: In 4-day proliferation assays, buparvaquone efficiently inhibits N. caninum tachyzoite replication(IC₅₀=4.9 nM; IC₁₀₀=100 nM). Buparvaquone is significantly selective against L. (L.) infantum chagasi intracellular amastigotes, with an IC₅₀ value of 1.5 μM. Other cutaneous species are also susceptible to buparvaquone, with IC₅₀ values in the range 1-4 μM.

In Vivo: Treatment of N. caninum infected mice with buparvaquone (100 mg/kg) either by intraperitoneal injection or gavage prevents neosporosis symptoms in 4 out of 6 mice in the intraperitoneally treated group, ａnd in 6 out of 7 mice in the group receiving oral treatment. Both a hydrous gel ａnd water-in-oil emulsion of buparvaquone significantly reduce cutaneous parasite burden ａnd lesion size, compared with the untreated control.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Natural Product Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Antiparasitic Compound library  |  Microbial Metabolite Library  |  Rapamycin  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Cycloheximide  |  Chloroquine  |  Dexamethasone  |  Staurosporine  |  Doxycycline (hyclate)  |  G-418 disulfate  |  Cyclosporin A  |  Actinomycin D  |  5-Azacytidine  |  Etoposide  |  Nigericin sodium salt  |  Mitomycin C  |  Brefeldin A  |  Resveratrol  |  Wortmannin  |  Tunicamycin  |  Bleomycin sulfate  |  Hygromycin B  |  Tacrolimus  |  Hydroxychloroquine sulfate  |  Ionomycin  |  Vancomycin hydrochloride  |  Streptozocin  |  Tanespimycin  |  Oligomycin A

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。