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(-)-Epicatechin

CAS No. : 490-46-0

MCE 站：(-)-Epicatechin

产品活性：(-)-Epicatechin 抑制环加氧酶-1 (COX-1) , IC₅₀为 3.2 μM。(-)-Epicatechin 通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。

研究领域：Immunology/Inflammation  |  Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：COX  |  Ferroptosis  |  Endogenous Metabolite

In Vitro: (-)-Epicatechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. In RINm5F cells, (-)-Epicatechin is shown to block the inhibition of insulin release after addition of IL-1β. Additionally, (-)-Epicatechin is shown to inhibit the proliferation of Hodgkin＇s lymphoma cells ａnd Jurkat T cells, which is attributed to the ability of (-)-Epicatechin to inhibit the binding of NF-κB to DNA in these cells. In human colorectal cancer HCT-116 cells, combining 20 μM Panaxadiol with 150, 200, or 250 μM (-)-Epicatechin results in growth inhibition of 51%, 97%, ａnd 95%, respectively. The combination also increases the apoptosis level by 11.9%, 16.6%, ａnd 25.8%, as examined by annexin V/PI staining.

In Vivo: Animals receive 1 mg/kg of (-)-Epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups undergo 15 days of treadmill exercise. Significant increases in treadmill performance (~50%) ａnd enhanced in situ muscle fatigue resistance (~30%) are observed with (-)-Epicatechin.

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