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Alantolactone

CAS No. : 546-43-0

MCE 站：Alantolactone

产品活性：Alantolactone 是 STAT3 的选择性抑制剂，并具有抗肿瘤活性。Alantolactone 可诱导癌症相关的凋亡。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis  |  TGF-beta/Smad

作用靶点：STAT  |  Apoptosis  |  TGF-beta/Smad

In Vitro: Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner. This Alantolactone-induced apoptosis is found to be associated with GSH depletion, inhibition of STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, ａnd increased Bax/Bcl-2 ratio ａnd caspase-3 activation. Alantolactone decreases STAT3 translocation to the nucleus, its DNA-binding, ａnd STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs ａnd on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases.
Alantolactone induces activin/SMAD3 signaling in human colon adenocarcinoma HCT-8 cells. Alantolactone performs its antitumor effect by interrupting the interaction between Cripto-1 ａnd the activin receptor type IIA in the activin signaling pathway.
Alantolactone (5 μg/mL, 24 h) inhibits cell proliferation in colon adenocarcinoma HCT-8 cells.

In Vivo: It is found that the average tumor volume in the Alantolactone-treated mice is approximately 2.17-fold lower compared with that in the control mice. However the administration of Alantolactone does not affect the overall bodyweight during the experimental period, suggesting no apparent toxicity. Additionally, the average tumor weight is significantly lower in the Alantolactone-treated mice compared with the control mice. What’s more, the administration of Alantolactone results in a significant decrease in p-STAT3 ａnd cyclin D1 expression in the tumor tissues.

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