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Psoralen

CAS No. : 66-97-7

MCE 站：Psoralen

产品活性：Psoralen (Ficusin) 是从补骨脂种子中提取的一种香豆素。Psoralen 具有多种生物学特性，包括抗癌、抗氧化、抗抑郁、抗癌、抗菌、抗病毒等。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Apoptosis  |  HIV  |  Influenza Virus

In Vitro: Psoralen (10-500 μM; 24-48 hours) inhibits cell viability in a concentration- ａnd time-dependent manner in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM does not significantly change extracellular LDH levels, ａnd 400 μM or 450 μM psoralen inhibits 50–60% of cell viability.
Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in time- ａnd dose-dependent manners, but it does not exhibits significant change in the cycle distribution of HepG2 cells.

In Vivo: Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) reduces the number of metastatic lesions ａnd the rate of bone metastasis by 20% compared to vehicle-treated mice. It also reduces tumor infiltration ａnd decreases the percentage of tumor cells in metastatic lesions by ~40% compared to vehicle in mice.

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