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Macelignan

CAS No. : 107534-93-0

MCE 站：Macelignan

产品活性：Macelignan ((+)-Anwulignan; Anwuligan) 是一种从肉豆蔻中分离得到的生物活性木脂素 (lignan)。Macelignan 具有多种药理活性，包括抗炎、抗癌、抗糖尿病和神经保护活性。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm², reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.
Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.

In Vivo: Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ-db/db mice.

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