MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ginkgolic Acid

CAS No. : 22910-60-7

MCE 站：Ginkgolic Acid

产品活性：Ginkgolic Acid是一种天然化合物， 在体外实验中抑制 SUMOylation 的 IC₅₀ 为3.0 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：E1/E2/E3 Enzyme

In Vitro: Ginkgolic acid inhibits the in vitro SUMOylation of RanGAP1-C2 with the IC₅₀ values of 3.0 μM. The level of SUMOylated p53 is markedly reduced by the ginkgolic acid treatment. Importantly, ginkgolic acid does not affect protein ubiquitination in cells. Ginkgolic acid inhibits the binding between E1 ａnd GA-BODIPY in a dose-dependent manner. Ginkgolic acid (31.2 μg/mL) inhibits HIV protease activity by 60%, compared with the negative control, ａnd the effect is concentration-dependent. Ginkgolic acid treatment (50 ａnd 100 μg/mL) effectively inhibits HIV infection in human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells. GA only inhibits the growth of tumorogenic cell lines in a both dose- ａnd time-dependent manner. Tumor cells are treated with GA for 72 h, 70.53±4.54% Hep-2 ａnd 63.5±7.2% Tca8113 cells are retarded at GO/G1 phase, ａnd the percentage of apoptosis is 40.4±1.58 ａnd 38.4±1.7%, respectively. GA-treated activated caspase-3 downregulates the expression of anti-apoptotic Bcl-2 protein ａnd upregulates the expression of pro-apoptotic Bax protein, eventually leading to a decrease in the Bcl-2/Bax ratio in tumor cellsin human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Ubiquitination Compound Library  |  Phenols Library  |  Traditional Chinese Medicine Monomer Library  |  Food-Sourced Compound Library   |  TAK-243  |  Idasanutlin  |  Nutlin-3a  |  AMG 232  |  ML-792  |  Subasumstat  |  Mezigdomide  |  PYR-41  |  RG7112  |  BI8622  |  2-D08  |  Siremadlin  |  Avadomide  |  SZL P1-41  |  MD-224  |  C25-140  |  NSC232003  |  PRT4165  |  Indole-3-carbinol  |  BI8626  |  MI-773  |  Milademetan  |  NAcM-OPT  |  Skp2 Inhibitor C1  |  MI-1061  |  NVP-CGM097  |  Alrizomadlin  |  LS-102

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。