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Dihydromyricetin

CAS No. : 27200-12-0

MCE 站：Dihydromyricetin

产品活性：Dihydromyricetin 是一种有效的二氢嘧啶酶 (dihydropyrimidinase) 抑制剂，IC₅₀ 为 48 μM。Dihydromyricetin 可通过抑制 mTOR 信号从而激活自噬。Dihydromyricetin 抑制 mTOR 复合体 (mTORC1/2) 形成。Dihydromyricetin 还是一种流感依赖 RNA 的 RNA 聚合酶抑制剂，IC₅₀ 为 22 μM。

研究领域：PI3K/Akt/mTOR  |  Anti-infection  |  Cell Cycle/DNA Damage  |  Autophagy

作用靶点：mTOR  |  Influenza Virus  |  DNA/RNA Synthesis  |  Autophagy

In Vitro: Dihydromyricetin, a flavonol, significantly inhibits the catalytic activities of dihydropyrimidinase toward both the natural substrate dihydrouracil ａnd xenobiotic substrate 5-propyl-hydantoin. Dihydromyricetin exhibits a significant inhibitory effect on the activities of dihydropyrimidinase for both substrates, even more than Myricetin does. The IC₅₀ values of Dihydromyricetin for dihydropyrimidinase determined from the titration curves using Dihydrouracil ａnd 5-propyl-hydantoin are 48±2 ａnd 40±2 μM, respectively. Dihydromyricetin (DHM) supplementation significantly reverses the increased phosphorylation of mTOR at Ser²⁴⁴⁸ (p-mTOR) during D-gal administration, which suggests that Dihydromyricetin can activate autophagy through inhibiting mTOR signaling.

In Vivo: Changes in learning ａnd memory capacity in rats administrated normal control group, D-gal group, D-gal+Dihydromyricetin (100 mg/kg) group, D-gal+Dihydromyricetin (200 mg/kg) group assessed by morris water maze (MWM) (n=10 per group). Dihydromyricetin (DHM) treatment significantly shortens the escape latency when compared with D-gal-induced model group.

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