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Ursolic acid

CAS No. : 77-52-1

MCE 站：Ursolic acid

产品活性：Ursolic acid (Prunol) 是一天然三萜羧酸化合物，具有预防和抗癌活性。

研究领域：Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Autophagy  |  Endogenous Metabolite

In Vitro: UA induced phosphorylation of AMP-activated protein kinase alpha (AMPKα) ａnd suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner [1]. The combination of ursolic acid (0.5 μM) ａnd leucine (10 μM) proved to be the most effective in promoting myogenic differentiation. The combination of ursolic acid ａnd leucine significantly increased CK activity than treatment with either agent alone. The level of myosin heavy chain, a myogenic differentiation marker protein, was also enhanced by the combination of ursolic acid ａnd leucine [2]. Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein ａnd the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase ａnd c-Jun N-terminal kinase was increased by the administration of ursolic acid. In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells ａnd significantly decreased the expression of matrix metalloproteinase (MMP)-2 [3]. ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 ａnd apoptosis [4].

In Vivo: UA treatment markedly improved the survival of septic rats, ａnd attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes ａnd proteins, myeloperoxidase activity, ａnd malondialdehyde content. In addition, UA significantly decreased the serum levels of tumor necrosis factor-α, interleukin-6, ａnd interleukin-1β, inhibited the expression of inducible nitric oxide synthase ａnd cyclooxygenase-2 in the lung, which are involved in the productions of nitric oxide ａnd prostaglandin E2 [5].

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