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(-)-Epigallocatechin

CAS No. : 970-74-1

MCE 站：(-)-Epigallocatechin

产品活性：(-)-Epigallocatechin (Epigallocatechin) 是绿茶中*丰富的类黄酮，能结合未折叠多肽和防止转化为淀粉样纤维。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：MMP  |  Autophagy

In Vitro: (-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that (-)-Epigallocatechin prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin ａnd EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot ａnd immunoprecipitation analyses revealed that curcumin ａnd (-)-Epigallocatechin (EGC) specifically inhibited STAT3 phosphorylation ａnd STAT3-NFkB interaction was retained [2]. (-)-Epigallocatechin (EGC) exhibits a MIC ａnd MBC of 5 μg/mL ａnd 20 μg/mL respectively ａnd effectively eradicated E. faecalis biofilms. (-)-Epigallocatechin induces the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, (-)-Epigallocatechin induces significant down-regulation of E. faecalis virulence genes [3].

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