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Calcium Ion Channel Library

MCE 站：Calcium Ion Channel Library

Calcium Ion Channel Library contains about 10,560 compounds, ａnd designed for discovery of new Voltage-gated calcium channel blockers. Calcium ion channels are responsible for an unusually large variety of physiological functions. Calcium ions entering the cell through voltage-gated channels serve as the second messenger of electrical signaling, initiating many different cellular events. Calcium Ion Channel Library encompasses both known chemotypes ａnd molecules based on novel scaffolds identified in their in silico studies ａnd MedChem based scaffold hopping projects.

Description & Advantages:

•   86% compounds in the library are lead-likeness, the average Fsp3 is 0.38, the average TPSA is 60.5 Å2.

•   Privileged chemotypes, such as dihydropyridines, GABA-analogues, succinimides, 4-substituted prolines, ａnd quinazolines.

•   Unique analogues of piperazine ａnd 4-aminopiperidine.

•   Drug like compounds with novel chemotypes, the most attractive structural ａnd physical chemical properties.

•   Databases ａnd compounds are provided by Enamine.

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
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•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
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