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Sodium Ion Channel Library

MCE 站：Sodium Ion Channel Library

Sodium Ion Channel Library contains about 5,440 compounds, ａnd designed for discovery of new Nav1.7 channel blockers. Sodium voltage-gated ion channel is considered to be an important component in nociception. Therefore, selective Nav1.7 channel blockers are considered as important novel analgesics. The Sodium Ion Channel Library is rich in compounds bearing saturated backbones that can be often seen in structures of other ion-channel blockers.

Description & Advantages:

•   Compound rich in saturated skeleton that can be often seen in structures of other ion-channel blockers.

•   All compounds meet requirements of Ro5, ａnd 67% compounds are considered lead-like.

•   The most abundant are relatively flat aromatic cores.

•   Presence of highly polar backbone fragments/moieties (e.g. CONH2, SO2NHR, polar heterocycles, etc).

•   Databases ａnd compounds are provided by Enamine.

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