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Z-Ile-Leu-aldehyde

CAS No. : 161710-10-7

MCE 站：Z-Ile-Leu-aldehyde

产品活性：Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：Notch  |  γ-secretase  |  Apoptosis

In Vitro: Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.

In Vivo: Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells ａnd possibly in osteoclasts in their microenvironment.

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