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Senazodan hydrochloride

CAS No. : 98326-33-1

MCE 站：Senazodan hydrochloride

产品活性：Senazodan (MCI 154) (hydrochloride) 是一种 Ca²⁺ 感光剂，同时可抑制 PDE III 的活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphodiesterase (PDE)

In Vitro: Senazodan (hydrochloride) seems to affect directly the actin-myosin crossbridge kinetics, ａnd increases myosin ATPase activity. Senazodan (hydrochloride) produces a concentration-dependent increase in tension development. Senazodan (hydrochloride) enhances Ca²⁺ binding to myofilaments ａnd to purified cardiac troponin C. Senazodan (hydrochloride) also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III.Senazodan (0.1 nM~0.1 mM) (hydrochloride) shows that the contractile response of superior mesenteric arterie (SMA) to norepinephrine (NE) after hemorrhagic shock is significantly decreased as compared with the normal control group. Senazodan (0.01 mM) (hydrochloride) pretreatment prevents the effects of Ang II, ａnd the concentration-response curve of Ca²⁺ is shifted to the right as compared with Ang II-alone group.

In Vivo: Senazodan (0.1~2.0 mg/kg; left femoral vein catheterization infusion) (hydrochloride) decreases the pressor effect of norepinephrine (NE).
Senazodan (0.1 mg/kg; i.v.) (hydrochloride) makes LVSP, IP, MC, ａnd Lo all increased significantly, while heart rate is not obviously changed ａnd left ventricular end-diastolic pressure (LVEDP) is reduced remarkably.

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