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Z-FY-CHO

CAS No. : 167498-29-5

MCE 站：Z-FY-CHO

产品活性：Z-FY-CHO (Z-Phe-Tyr-CHO) 是一种有效且特异性的组织蛋白酶 L (CTSL) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cathepsin

In Vitro: Z-FY-CHO (10 µM, for 1 h) pretreatment alleviated cell death induced by 6-OHDA. Z-FY-CHO inhibits the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells. Treatment with Z-FY-CHO caused more LC3-II ａnd less P62 expression in SH-SY5Y cells treated with 6-OHDA, indicating enhancing autophagy activity, ａnd Z-FY-CHO blocks activation of caspase-3 ａnd PARP.
Treatment with the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA significantly increased the radiosensitivity of U251 cells. Both suppression ａnd knockdown of cathepsin L in U251 cells increased irradiation-induced DNA damage ａnd G2/M phase cell cycle arrest. Both suppression ａnd knockdown of cathepsin L in U251 cells also increased irradiation-induced apoptosis, as shown by the increased levels of Bax ａnd decreased levels of Bcl-2.

In Vivo: Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation.

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