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Fucoidan

CAS No. : 9072-19-9

MCE 站：Fucoidan

产品活性：Fucoidan 是一种生物活性多糖，是 α-淀粉酶和 α-葡萄糖苷酶的有效抑制剂。 具有抗凝血，抗肿瘤，抗氧化和抗脂肪活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Glucosidase

In Vitro: Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae.
Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC₅₀ ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC₅₀=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC₅₀ of 0.12-4.64 mg/mL.
Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress.

In Vivo: Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth ａnd metastasis.

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