MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

U-104

CAS No. : 178606-66-1

MCE 站：U-104

产品活性：U-104 (SLC-0111) 是一种有效的 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂，K_i 值分别为 45.1 nM 和 4.5 nM。U-104 在小鼠模型中显示出明显的肿瘤生长延迟。

研究领域：Metabolic Enzyme/Protease

作用靶点：Carbonic Anhydrase

In Vitro: U-104 (SLC-0111) is a potent exosome inhibitor.
U-104 has low inhibition for CA I (K_i=5080 nM) ａnd CA II (K_i=9640 nM).
U-104 (50 μM; for 72 hours) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4^Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells.

In Vivo: U-104 (19, 38 mg/kg; daily; for 27 days) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg; daily; for 5 days) inhibits metastases formation in the 4T1 experimental metastasis mice model.
U-104 (38 mg/kg; i.p.; from 11 to 27 days) significantly delays primary tumor growth ａnd reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4^Luc+ cells.
U-104 (50 mg/kg; oral gavage; continuously for 4 days ａnd suspended for 1 day; from 10 to 30 days) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells.

相关产品：Covalent Screening Library Plus  |  Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Peptidomimetic Library  |  Drug Repurposing Compound Library  |  Covalent Screening Library  |  Exosomes Compound Library  |  Indisulam  |  Acetazolamide  |  Methazolamide  |  Zonisamide  |  Ethoxzolamide  |  Topiramate  |  Brinzolamide  |  Benzthiazide  |  Dorzolamide hydrochloride  |  Tioxolone  |  Sultiame  |  Dichlorphenamide  |  2-Aminobenzenesulfonamide  |  Benzolamide  |  EMAC10101d  |  Fluorometholone acetate  |  Dimethylfraxetin  |  Halazone  |  CAIX Inhibitor S4  |  Dorzolamide-d5  |  Methyclothiazide  |  Topiramate D12

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。