MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Doxorubicinol hydrochloride

CAS No. : 63950-05-0

MCE 站：Doxorubicinol hydrochloride

产品活性：Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) 是 Doxorubicin 的仲醇代谢物。

研究领域：Metabolic Enzyme/Protease

作用靶点：Drug Metabolite

In Vitro: Doxorubicinol hydrochloride is produced by a two-electron, NADPH-dependent reduction of the Doxorubicin side-chain carbonyl group (C13) to a secondary alcohol.
Doxorubicinol hydrochloride has been shown to have significantly lower DNA binding activity as compared to DOX. Moreover, while Doxorubicinol hydrochloride is retained in the cytoplasm or lysosomes, Doxorubicin is mainly accumulated in the nucleus.

In Vivo: In vivo, in tumor-bearing mice, Nilotinib, acting as ABCB1 inhibitor, is found to increase the accumulation of Doxorubicin ａnd Doxorubicinol hydrochloride in cancer tissues. This implies that weaker anticancer activity of Doxorubicinol hydrochloride may be related to its increased affinity to ABC transporters, thus leading to a lower intracellular concentration of the agent.
In comparison with wild-type mice, the terminal half-life ａnd the area under the plasma concentration-time curve of Doxorubicin in mdr1a(-/-) mice are 1.6- ａnd 1.2-fold higher respectively. The retention of both Doxorubicin ａnd its metabolite Doxorubicinol hydrochloride in the hearts of mdr1a(-/-) mice is substantially prolonged.

相关产品：Clozapine N-oxide  |  Oseltamivir acid  |  GS-443902 trisodium  |  Urolithin A  |  Mycophenolate Mofetil  |  Nortriptyline hydrochloride  |  Phosphoramide mustard (cyclohexanamine)  |  3-Methoxytyramine hydrochloride  |  4-Hydroperoxy cyclophosphamide  |  AZ7550 hydrochloride  |  Endoxifen hydrochloride  |  Hydroxy Itraconazole  |  Monomethyl fumarate  |  Cycloguanil hydrochloride  |  Palifosfamide  |  Deslanoside  |  Ercalcitriol  |  GS-704277  |  Clofibric acid  |  Ezetimibe phenoxy glucuronide  |  Remdesivir nucleoside monophosphate  |  (±)-Equol  |  24, 25-Dihydroxy VD2  |  N-Desmethyltamoxifen hydrochloride  |  OR-1896  |  Desmethyl Erlotinib hydrochloride  |  N-Desmethylclozapine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。