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CPS2

CAS No. :

MCE 站：CPS2

产品活性：CPS2是一种高效、选择性、不可逆的 PROTAC CDK2 降解剂 (IC₅₀= 24 nM)。CPS2 可用于研究急性髓系白血病。

研究领域：Cell Cycle/DNA Damage

作用靶点：CDK

In Vitro: CPS2 (5~333 nM; 12 hours; Ramos cells) stands out as the most potent degrader.
CPS2 (0.5~2 μM; HSCs) inhibits the proliferation of HSCs without inducing cytotoxicity. CPS2 (1~10000 nM; 48 hours; NB4 cells) induces potent CDK2 degradation. CPS2 (250 nM; 0~6 hours; Ramos ａnd NB4 cells) rapidly induces the degradation of CDK2. CPS2 (10~500 nM; 6 hours; Ramos cells) induces only CDK2 degradation ａnd does not directly perturb the other CDK proteins under subnanomolar concentration conditions. CPS2 (250 nM; 6 hours; NB4 cells) stands out as the most downregulated protein in cells treated for 6 hours with CPS2, confirming the selectivity of CPS2 for CDK2. CPS2 (0~250 nM; NB4 cells) makes the levels of CDK2 obviously decreased. CPS2 (2 μM; 3 days; HL60 cells) obviously promotes ATRA-induced CD11b upregulation.
The antileukemic effects of CPS2 are mediated by CDK2 degradation. CPS2 also induces granulocytic differentiation of HSCs, as assessed by cell morphological analysis.

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