MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Targaprimir-96 TFA

CAS No. :

MCE 站：Targaprimir-96 TFA

产品活性：Targaprimir-96 TFA 是 microRNA-96 (miR-96) 加工的有效抑制剂。Targaprimir-96 TFA 选择性地调节癌细胞中 miR-96 的产生并触发凋亡 (apoptosis)。Targaprimir-96 TFA 高亲和力的与 primary miR-96 (pri-miR-96) 结合。Targaprimir-96 TFA 直接与乳腺癌细胞中的 pri-miR-96 结合，并不影响健康乳腺细胞。

研究领域：Epigenetics  |  Apoptosis

作用靶点：MicroRNA  |  Apoptosis

In Vitro: Targaprimir-96 TFA shows a dose-response in MDA-MB-231 triple negative breast cancer cells with an IC₅₀ of ~50 nM by assessing the reduction of mature miR-96 levels. Targaprimir-96 (50 nM) TFA boosts the amount of the pri-miRNA ａnd decreases the levels of the pre-miRNA ａnd mature miRNA in a dose-dependent manner.
Targaprimir-96 TFA (50 nM; 48 hours) increases FOXO1 levels ａnd triggers apoptosis in breast cancer cell line 4175.
Targaprimir-96 TFA binds RNA3 (contains both the Drosha site ａnd the adjacent 1×1 nt GG internal loop) with a K_d of 85 nM. Targaprimir-96 binds RNA1, RNA2, RNA4, ａnd RNA5 with K_d values of 1.2, 0.9, 1.2, ａnd 1.5 μM, respectively. Thus, Targaprimir-96 TFA is highly RNA-selective ａnd recognizes both the 1×1 nt GG ａnd 1×1 nt UU loops to provide high affinity, effectively discriminating against a variety of related targets.

In Vivo: Targaprimir-96 TFA (10 mg/kg; i.p.; every other day for 21 days) inhibits tumor growth in a mouse model of triple-negative breast cancer (TNBC).
The amount of Targaprimir-96 (2 or 7 mg/kg; i.p.) in plasma peaks is ~4 h in FVB/n mice. Importantly, even 48 hours postinjection, the concentration of Targaprimir-96 TFA remaining in plasma is much greater than the 50 nM cellular concentration that triggered apoptosis: 1.6 μM for the 2 mg/kg dosage ａnd 1.9 μM for the 7 mg/kg dosage.

相关产品：MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Y-27632 dihydrochloride  |  Paclitaxel  |  Acetylcysteine  |  Angiotensin II human  |  Staurosporine  |  Bortezomib  |  5-Fluorouracil  |  Sorafenib  |  Tamoxifen  |  SP600125  |  Trametinib  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Temozolomide  |  MK-2206 dihydrochloride  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Etoposide  |  Pexidartinib  |  BAY 11-7082  |  CCCP  |  DAPT  |  Ruxolitinib  |  Mitomycin C

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。