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Dimethyl-SGD-1882

CAS No. :

MCE 站：Dimethyl-SGD-1882

产品活性：Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂，能抑制 DNA 复制。

研究领域：Antibody-drug Conjugate/ADC Related

作用靶点：ADC Cytotoxin

In Vitro: The unique structure of the pyrrolobenzodiazepine (PBD) dimers which contain two alkylating imine functionalities allows them to form interstrand or intrastrand DNA cross‐links in addition to mono‐alkylated adducts, thus resulting in greater DNA stabilization compared to monomeric PBDs. Due to the additional types of DNA adducts possible ａnd the greater adduct stability, the C8‐linked PBD dimers generally have significantly greater cytotoxicity, antitumor activity ａnd antibacterial activity compared to PBD monomers, ａnd one such agent, SJG‐136, has reached Phase II clinical trials in ovarian cancer ａnd leukaemia. Furthermore, related PBD dimers are now being used as payloads for antibody-drug conjugates (ADCs) due to their significant cytotoxicity.

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