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Fluoxetine hydrochloride

CAS No. : 56296-78-7

MCE 站：Fluoxetine hydrochloride

产品活性：Fluoxetine hydrochloride (LY 110140) 是抗抑郁药和选择性的血清素重吸收抑制剂。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：Serotonin Transporter  |  Autophagy

In Vitro: Fluoxetine hydrochloride (LY 110140) blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine ａnd sertraline, increases norepinephrine ａnd dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust ａnd sustained increases in extracellular concentrations of norepinephrine ａnd dopamine after acute systemic administration.

In Vivo: Fluoxetine hydrochloride (LY 110140) treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) ａnd norepinephrine ([NE](ex)) up to 361% ａnd 272% of the baseline, respectively, which are significantly greater than either drug alone.

相关产品：Paroxetine hydrochloride  |  Imipramine hydrochloride  |  Fluvoxamine maleate  |  Desipramine hydrochloride  |  Sertraline hydrochloride  |  Duloxetine hydrochloride  |  Amitriptyline hydrochloride  |  Clomipramine hydrochloride  |  Citalopram hydrobromide  |  Venlafaxine hydrochloride  |  Escitalopram oxalate  |  Vortioxetine hydrobromide  |  Dapoxetine hydrochloride  |  Vilazodone  |  Dasotraline hydrochloride  |  Centanafadine hydrochloride  |  Amitifadine hydrochloride  |  Cinchonidine  |  Milnacipran hydrochloride  |  Azaphen dihydrochloride monohydrate  |  Desvenlafaxine

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