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Doxefazepam

CAS No. : 40762-15-0

MCE 站：Doxefazepam

产品活性：Doxefazepam 是一种苯并二氮 (benzodiazepine) 衍生物。具有抗焦虑，抗惊厥，镇静的作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vivo: Groups of 50 male ａnd 50 female Sprague-Dawley rats are given food containing sufficient Doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. Rats are treated for 104 weeks ａnd then euthanized. An extensive autopsy is performed on those animals that died intercurrently ａnd on euthanized animals. The chronic administration of Doxefazepam does not influence the survival of the rats. A significant linear trend in the incidence of hepatocellular neoplasms, primarily benign, is observed in the female treated groups. This higher incidence is not associated to a higher occurrence of focal hyperplasia or other preneoplastic lesions in treated rats. The brain, a target organ for the pharmacological activity of Doxefazepam, is carefully examined to search for microscopic foci of proliferative cells. A total of 12 ａnd 6 malignant gliomas are observed in male ａnd female rats, respectively; only two are noticed at autopsy. These tumors are mainly of the oligodendroglioma type commonly found in aged rats. Doxefazepam is investigated in a series of toxicological studies. Oral LD₅₀ values are greater than 2000 mg/kg in mice, rats ａnd dogs, while endoperitoneal LD₅₀ values are 746 ａnd 544 mg/kg in the mice ａnd rats, respectively, ａnd greater than 1000 mg/kg in the dogs.

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