MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Carboxy-PTIO

CAS No. : 145757-47-7

MCE 站：Carboxy-PTIO

产品活性：Carboxy-PTIO 是一种有效的一氧化氮 (NO) 清除剂，能与 NO 快速反应产生 NO₂。Carboxy-PTIO 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用，可预防低血压和内毒素休克。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.
Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 ａnd PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.
Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR ａnd p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells.

In Vivo: Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction ａnd survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.

相关产品：Mifepristone  |  L-NAME hydrochloride  |  1400W Dihydrochloride  |  L-NMMA acetate  |  L-Arginine  |  S-Nitroso-N-acetyl-DL-penicillamine  |  Methylene Blue  |  Isoquercetin  |  Aminoguanidine hydrochloride  |  Asymmetric dimethylarginine  |  Chondroitin sulfate  |  Tetrahydrobiopterin  |  L-NIL  |  2,4-Diamino-6-hydroxypyrimidine  |  Tat-NR2B9c TFA  |  6-Biopterin  |  DETA NONOate  |  Ginsenoside Rb3  |  Ginsenoside C-K  |  L-NIO dihydrochloride  |  Madecassic acid  |  Isosorbide dinitrate  |  L-Canavanine sulfate  |  Pectolinarin  |  GW274150  |  Agmatine sulfate  |  TP508 TFA

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。